催化作用
淀粉样蛋白(真菌学)
化学
淀粉样纤维
纤维
细胞毒性
生物化学
生物物理学
淀粉样β
生物
体外
医学
无机化学
疾病
病理
出处
期刊:Methods in Enzymology
日期:2024-01-01
被引量:1
标识
DOI:10.1016/bs.mie.2024.01.014
摘要
Amyloid fibrils have been identified in many protein systems, mostly linked to progression and cytotoxicity in neurodegenerative diseases and other pathologies, but have also been observed in normal physiological systems. A growing body of work has shown that amyloid fibrils can catalyze chemical reactions. Most studies have focused on catalysis by de-novo synthetic amyloid-like peptides; however, recent studies reveal that physiological, native amyloids are catalytic as well. Here, we discuss methodologies and major experimental aspects pertaining to physiological catalytic amyloids. We highlight analyzes of kinetic parameters related to the catalytic activities of amyloid fibrils, structure-function considerations, characterization of the catalytic active sites, and deciphering of catalytic mechanisms.
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