致密部
黑质
多巴胺
MPTP公司
纹状体
多巴胺能
兴奋剂
多巴胺受体D2
帕金森病
多巴胺受体
神经科学
药理学
医学
生物
受体
内科学
内分泌学
疾病
作者
Hongli Li,Min Gao,Ziyu Chen,Zhenyu Zhou,Wei Li,Xiaoyang Zhang,Xi Jiang,Lingling Luo,Fĕi Li,Gaorui Wang,Yu Zhang,Xingxu Huang,Jing‐Ning Zhu,Shengjie Fan,Xiaojun Wu,Cheng Huang
摘要
Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the striatum, leading to dopamine (DA) deficiency in the striatum and typical motor symptoms. A small molecule as a dietary supplement for PD would be ideal for practical reasons. Hordenine (HOR) is a phenolic phytochemical marketed as a dietary supplement found in cereals and germinated barley, as well as in beer, a widely consumed beverage. This study was aimed to identify HOR as a dopamine D2 receptor (DRD2) agonist in living cells, and investigate the alleviative effect and mechanism of HOR on PD-like motor deficits in mice and nematodes. Our results firstly showed that HOR is an agonist of DRD2, but not DRD1, in living cells. Moreover, HOR could improve the locomotor dysfunction, gait, and postural imbalance in MPTP- or 6-OHDA-induced mice or Caenorhabditis elegans, and prevent α-synuclein accumulation via the DRD2 pathway in C. elegans. Our results suggested that HOR could activate DRD2 to attenuate the PD-like motor deficits, and provide scientific evidence for the safety and reliability of HOR as a dietary supplement.
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