Association of air pollution and genetic risks with incidence of elderly-onset atopic dermatitis: A prospective cohort study

医学 特应性皮炎 入射(几何) 环境卫生 前瞻性队列研究 人口 队列 队列研究 空气污染 遗传倾向 混淆 人口学 内科学 免疫学 生物 疾病 生态学 物理 社会学 光学
作者
Xiaoyu Gu,Danrong Jing,Yi Xiao,Guowei Zhou,Songchun Yang,Hong Liu,Xiang Chen,Minxue Shen
出处
期刊:Ecotoxicology and Environmental Safety [Elsevier BV]
卷期号:253: 114683-114683 被引量:9
标识
DOI:10.1016/j.ecoenv.2023.114683
摘要

Elderly-onset atopic dermatitis (AD) is a remarkable subtype and has been put on the agenda owing to its difficulty to control. Understanding the influence of genetic and environmental exposures is crucial to preventing elderly-onset AD.To explore the association between genes and air pollution on incident elderly-onset AD.This study was based on UK Biobank that recruited over 500,000 participants. The genetic risks were categorized into low, intermediate, and high groups according to tertiles of polygenic risk scores. Mixed exposure to various air pollutants was assessed using the weighted quantile sum (WQS) and also categorized based on tertiles. Within each genetic risk group, whether air pollutant mixture was associated with incident elderly-onset AD was estimated.337,910 participants were included in the final analysis, and the mean age was 57.1. The median years for follow-up were 12.0, and the incident cases of AD were 2545. The medium and high air pollution mixture was significantly associated with incident AD compared with the low pollution group, with HRs of 1.182 (P = 0.003) and 1.359 (P < 0.001), respectively. In contrast, HR for medium and high genetic susceptibility was only 1.065 (P = 0.249) and 1.153 (P = 0.008). The population-attributable fraction of air pollution and genetic risk was 15.5 % (P < 0.001) and 6.4 % (P = 0.004). Additionally, compared with low genetic risk and low air pollution, high genetic risk and high air pollution was significantly associated with the incidence of elderly-onset AD with a HR of up to 1.523 (P < 0.001). There were no interactive effects between each group of genetic risks and air pollution. When grouped by sex, females could observe a stronger effect by genetic and air pollutant mixture exposure.Air pollution and genetics both independently enhance the risk of newly developed AD, and the effect of air pollutants is stronger than the investigated genes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
李嘉蕊完成签到,获得积分10
刚刚
1秒前
Hello应助Xx采纳,获得10
1秒前
桐桐应助瓜瓜采纳,获得10
1秒前
苒苒完成签到,获得积分10
2秒前
友好小土豆完成签到,获得积分10
2秒前
大大小小发布了新的文献求助30
2秒前
2秒前
羽6完成签到,获得积分10
3秒前
高兴的半山完成签到,获得积分20
4秒前
吴玉婷发布了新的文献求助30
4秒前
顾矜应助DarwinZC采纳,获得10
4秒前
runner发布了新的文献求助10
5秒前
5秒前
刘壮实完成签到,获得积分10
5秒前
6秒前
6秒前
6秒前
7秒前
7秒前
luqong发布了新的文献求助10
7秒前
完美世界应助louis136116采纳,获得10
8秒前
8秒前
9秒前
10秒前
万能图书馆应助wutw采纳,获得10
10秒前
中中中完成签到,获得积分10
10秒前
汉堡包应助科研王子采纳,获得10
12秒前
还原糖发布了新的文献求助10
12秒前
13秒前
MgZn发布了新的文献求助10
13秒前
科研小子完成签到,获得积分10
14秒前
小二郎应助CJ采纳,获得10
14秒前
zjq4302完成签到,获得积分10
14秒前
louis136116完成签到,获得积分10
14秒前
15秒前
大个应助AI_S采纳,获得10
16秒前
科研小子发布了新的文献求助10
17秒前
18秒前
苏灿应助slow采纳,获得10
18秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974943
求助须知:如何正确求助?哪些是违规求助? 3519467
关于积分的说明 11198482
捐赠科研通 3255728
什么是DOI,文献DOI怎么找? 1797904
邀请新用户注册赠送积分活动 877261
科研通“疑难数据库(出版商)”最低求助积分说明 806224