Determination and Modeling of Artesunate Solubility in 13 Pure Solvents at 283.15–323.15 K

In this paper, the solubility of artesunate, a drug for the treatment of malaria, was determined by a laser dynamic method in 13 pure solvents (including seven alcohols and six esters) in the temperature range from 283.15 to 323.15 K under a pressure of 101.3 KPa. The solubility of artesunate in the 13 pure solvents increases with increasing temperature and follows the order: ethanol > amyl alcohol > propanol > methyl propionate > ethyl acetate > butanol > isopropanol > isobutanol ≈ isoamyl alcohol > propyl acetate > butyl acetate > isopropyl acetate > amyl acetate. Three semi-empirical models (modified Apelblat, three-parameter Van't Hoff, and λh model) and two activity coefficient models (Wilson and NRTL) have been used to correlate the experimental data. Moreover, the mixing thermodynamic properties (ΔmixG, ΔmixS, and ΔmixH) of solutions have been estimated using the solubility data and the regressed Wilson model parameters.