神经科学
突触
人口
星形胶质细胞
神经元
生物神经网络
工作记忆
运动前神经元活动
生物
神经活动
机制(生物学)
神经传递
物理
中枢神经系统
认知
医学
环境卫生
受体
量子力学
生物化学
作者
Maurizio De Pittà,Nicolas Brunel
标识
DOI:10.1073/pnas.2207912119
摘要
Persistent activity in populations of neurons, time-varying activity across a neural population, or activity-silent mechanisms carried out by hidden internal states of the neural population have been proposed as different mechanisms of working memory (WM). Whether these mechanisms could be mutually exclusive or occur in the same neuronal circuit remains, however, elusive, and so do their biophysical underpinnings. While WM is traditionally regarded to depend purely on neuronal mechanisms, cortical networks also include astrocytes that can modulate neural activity. We propose and investigate a network model that includes both neurons and glia and show that glia-synapse interactions can lead to multiple stable states of synaptic transmission. Depending on parameters, these interactions can lead in turn to distinct patterns of network activity that can serve as substrates for WM.
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