转移
癌症研究
Wnt信号通路
癌症
医学
结直肠癌
癌细胞
运动性
信号转导
生物
内科学
细胞生物学
作者
Lu Jiang,Ying-Jian Sun,Xiao‐Hua Song,Sun Yanyan,Wen-Yao Yang,Jing Li,Yi‐Jun Wu
出处
期刊:PubMed
日期:2022-01-01
卷期号:12 (10): 4502-4519
摘要
Tumor metastasis is the major cause of cancer mortality; therefore, it is imperative to discover effective therapeutic drugs for anti-metastasis therapy. In the current study, we investigated whether ivermectin (IVM), an FDA-approved antiparasitic drug, could prevent cancer metastasis. Colorectal and breast cancer cell lines and a cancer cell-derived xenograft tumor metastasis model were used to investigate the anti-metastasis effect of IVM. Our results showed that IVM significantly inhibited the motility of cancer cells in vitro and tumor metastasis in vivo. Mechanistically, IVM suppressed the expressions of the migration-related proteins via inhibiting the activation of Wnt/β-catenin/integrin β1/FAK and the downstream signaling cascades. Our findings indicated that IVM was capable of suppressing tumor metastasis, which provided the rationale on exploring the potential clinical application of IVM in the prevention and treatment of cancer metastasis.
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