抗氧化剂
激进的
化学
DPPH
多酚
没食子酸
抗氧化能力
涂层
有机化学
核化学
作者
Alexandra Lan,Yan Long Edmund Lui,Jinhui Zuo,Silke B. Lohan,Sabine Schanzer,Sabrina Wiemann,Cornelia M. Keck,Jürgen Lademann,Martina C. Meinke
出处
期刊:Cosmetics
[MDPI AG]
日期:2022-12-20
卷期号:10 (1): 1-1
被引量:2
标识
DOI:10.3390/cosmetics10010001
摘要
Antioxidants can reduce free radical formation in deeper skin layers where typical sunscreen filters may no longer be effective. Here, a general method is presented to pre-select optimum combinations of antioxidants and physical filters. The radical production of selected common physical filters after UV irradiation, the capacity of different antioxidants and the interaction between these compounds was investigated in solution by optical measurement of DPPH scavenging, allowing a theoretical calculation of the antioxidant amount necessary to scavenge UV-induced radicals. Furthermore, the antioxidant capacity and the scattering properties were determined. All physical filters induced different amounts of radicals in suspensions depending on the coating. ZnO coated with polydimethylsiloxane and myristic acid (ZnOpolymyr) showed the lowest radical formation. Epigallocatechin-gallate (EGCG) provided the highest antioxidant capacity. Different formulations with different ratios of selected physical filters and antioxidants were prepared. It turned out that the high radical protection factor (RPF) of cream formulations, which originally did not contain any physical filters, was reduced when such filters were added. The data demonstrates that the addition of physical filters to antioxidant-containing formulations lowers their reduction capacity, but to varying degrees. An optimal combination of physical filters and antioxidants must be pre-selected in order to incorporate them into a formulation and verify their effect on skin.
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