Self-assembly of antifungal agent 5-fluorocytosine and nutrient trans-p-coumaric acid furnishes a cocrystal with the potential to reduce toxicity and side effects for the drug: a case study combining theory with experiment

Cocrystallization of 5-fluorocytosine (FLCY) and trans-p -coumaric acid was first reported. Systematic studies combining theory with experiment revealed that both solubility and dissolution rate of FLCY can be down-regulated via cocrystallization.