上皮-间质转换
癌变
转移
生物
胰腺癌
癌症研究
转录因子
恶性转化
间充质干细胞
细胞迁移
细胞生物学
肿瘤进展
细胞
癌症
遗传学
基因
作者
Creighton Friend,Parash Parajuli,Mohammed S. Razzaque,Azeddine Atfi
出处
期刊:Advances in Cancer Research
日期:2023-01-01
卷期号:: 37-73
标识
DOI:10.1016/bs.acr.2023.02.008
摘要
Epithelial to mesenchymal transition (EMT) is a complex cellular program that alters epithelial cells and induces their transformation into mesenchymal cells. While essential to normal developmental processes such as embryogenesis and wound healing, EMT has also been linked to the development and progression of various diseases, including fibrogenesis and tumorigenesis. Under homeostatic conditions, initiation of EMT is mediated by key signaling pathways and pro-EMT-transcription factors (EMT-TFs); however, in certain contexts, these pro-EMT regulators and programs also drive cell plasticity and cell stemness to promote oncogenesis as well as metastasis. In this review, we will explain how EMT and EMT-TFs mediate the initiation of pro-cancer states and how they influence late-stage progression and metastasis in pancreatic ductal adenocarcinoma (PDAC), the most severe form of pancreatic cancer.
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