In memory of Professor Wei Jiang, a rising star in supramolecular chemistry

In conjunction with our research article in this issue of Chem, this essay is in memory of Professor Wei Jiang, a rising star in supramolecular chemistry who passed away on December 25th, 2022, from pancreatic cancer. We briefly summarize his research on bionic molecular recognition in water with diverse naphthotubes and their applications in multiple disciplines. Furthermore, we share the kind words of a few acquaintances of Prof. Jiang’s. In conjunction with our research article in this issue of Chem, this essay is in memory of Professor Wei Jiang, a rising star in supramolecular chemistry who passed away on December 25th, 2022, from pancreatic cancer. We briefly summarize his research on bionic molecular recognition in water with diverse naphthotubes and their applications in multiple disciplines. Furthermore, we share the kind words of a few acquaintances of Prof. Jiang’s. Reversible control of tetrazine bioorthogonal reactivity by naphthotube-mediated host-guest recognitionCao et al.ChemJune 15, 2023In BriefWe report a biocompatible and reversible strategy for controlling tetrazine-mediated IEDDA reactions through the high-affinity recognition of naphthotubes and phenyltetrazine. Through the modification of phenyltetrazine to different biomolecules, we have achieved reversible control of tetrazine reactivity on small molecules, carbohydrates, amino acids, nucleic acids, proteins, and living mammalian cells, even in animals. Site-specific naphthotube recognition of encoded tetrazine residues on proteins allows sequential fast IEDDA reactions to afford site-specific protein dual conjugates and different protein labeling in living cells. Full-Text PDF