神经调节
微气泡
超声波
计算机科学
相控阵
传感器
材料科学
生物医学工程
神经科学
刺激
工程类
医学
电气工程
放射科
电信
生物
天线(收音机)
作者
Ardavan Javid,Sheikh Jawad Ilham,Mehdi Kiani
出处
期刊:IEEE Transactions on Biomedical Circuits and Systems
[Institute of Electrical and Electronics Engineers]
日期:2023-07-28
卷期号:17 (5): 1084-1096
被引量:3
标识
DOI:10.1109/tbcas.2023.3299750
摘要
The invasiveness of neuromodulation technologies that require surgical implantation (e.g., electrical and optical stimulation) may limit their clinical application. Thus, alternative technologies that offer similar benefits without surgery are of paramount importance in the field of neuromodulation. Low-intensity ultrasound is an emerging modality for neural stimulation as ultrasound can be focused in deep tissues with millimeter resolution. Transcranial focused ultrasound stimulation (tFUS) has already been demonstrated in a wide range of animals and even humans at different sonication frequencies (mostly in the sub-MHz range due to the presence of the skull). This article first provides some fundamental knowledge in ultrasound, and then reviews various examples of successful tFUS experiments in animals and humans using different stimulation patterns, as well as available tFUS technologies for generating, focusing, and steering ultrasound beams in neural tissues. In particular, phased array technologies for the ultrasound stimulation application are discussed with an emphasis on the design, fabrication, and integration of ultrasound transducer arrays as well as the design and development of phased array electronics with beamformer and high-voltage driver circuitry. The challenges in tFUS, such as its underlying mechanism, indirect auditory response, and skull aberration effects, are also discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI