上睑下垂
炎症
发病机制
细胞生物学
程序性细胞死亡
细胞
医学
细胞凋亡
免疫学
化学
生物
炎症体
生物化学
作者
Xiaohan Liu,Peiyi Luo,Weiyun Zhang,Shuxian Zhang,Shu‐Long Yang,Fen‐Fang Hong
标识
DOI:10.1016/j.biopha.2023.115369
摘要
Pyroptosis is a pro-inflammatory type of regulated cell death (RCD) characterized by gasdermin protein-mediated membrane pore formation, cell swelling, and rapid lysis. Recent studies have suggested that pyroptosis is closely related to atherosclerosis (AS). Previous studies reported that pyroptosis involving endothelial cells (ECs), macrophages, and smooth muscle cells (SMCs) plays an important role in the formation and development of AS. Pyroptosis not only causes local inflammation but also amplifies the inflammatory response and it aggravates plaque instability, leading to plaque rupture and thrombosis, eventually resulting in acute cardiovascular events. In this review, we clarified some novel pathways and mechanics and presented some potential drugs.
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