疟疾
生物
病毒学
传输(电信)
疾病传播
免疫学
电信
计算机科学
作者
Wei Huang,Janneth Rodrigues,Etienne Bilgo,José R. Tormo,Joseph D. Challenger,Cristina De Cozar-Gallardo,Ignacio Pérez‐Victoria,Fernando Reyes,Pablo Castañeda-Casado,Edounou Jacques Gnambani,Domonbabele F. D. S. Hien,Maurice Konkobo,Beatriz Urones,Isabelle Coppens,Alfonso Mendoza-Losana,Lluís Ballell,Abdoulaye Diabaté,Thomas S. Churcher,Marcelo Jacobs‐Lorena
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2023-08-03
卷期号:381 (6657): 533-540
被引量:17
标识
DOI:10.1126/science.adf8141
摘要
Malaria control demands the development of a wide range of complementary strategies. We describe the properties of a naturally occurring, non–genetically modified symbiotic bacterium, Delftia tsuruhatensis TC1, which was isolated from mosquitoes incapable of sustaining the development of Plasmodium falciparum parasites. D. tsuruhatensis TC1 inhibits early stages of Plasmodium development and subsequent transmission by the Anopheles mosquito through secretion of a small-molecule inhibitor. We have identified this inhibitor to be the hydrophobic molecule harmane. We also found that, on mosquito contact, harmane penetrates the cuticle, inhibiting Plasmodium development. D. tsuruhatensis TC1 stably populates the mosquito gut, does not impose a fitness cost on the mosquito, and inhibits Plasmodium development for the mosquito’s life. Contained field studies in Burkina Faso and modeling showed that D. tsuruhatensis TC1 has the potential to complement mosquito-targeted malaria transmission control.
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