Electrochemical Determination of Tyrosine by a Silver Nanoparticle – Hollow Carbon Sphere Modified Glassy Carbon Electrode (GCE)

AbstractThe accurate and sensitive determination of tyrosine is of paramount value. In this work, we reported the synthesis and characterization of a new nanohybrid composed of silver nanoparticles and hollow carbon nanospheres (Ag/HMCS) for the amperometric sensing of tyrosine. The Ag/HMCS nanohybrid was used to modify electrodes and to fabricate an amperometric sensor for tyrosine at a working potential of 450 mV in aqueous 0.1 M phosphate buffer at pH 7.0. Under optimal conditions, the sensor determined tyrosine from 0.08 to 100 μM with a detection limit of 0.02 μM.Keywords: Ag nanoparticlesamperometrycyclic voltammetry (CV)electrochemical sensorglassy carbon electrodehollow carbon spherestyrosine AcknowledgmentsThe authors thank the Testing Center of Yangzhou University for the characterization experiments.Disclosure statementThe authors declare that they have no known competing financial interests or personal relationships that influenced the work reported in this paper.Additional informationFundingThe funding of this work was provided by the Natural Science Fund for Colleges and Universities in Jiangsu Province (19KJB550002) and State Key Laboratory of Analytical Chemistry for Life Science (SKLACLS2001), Nanjing University.