Impact of major hepatectomy on recurrence after resection of hepatocellular carcinoma at CNLC Ib stage: a propensity score matching study

医学 倾向得分匹配 肝细胞癌 肝切除术 危险系数 比例危险模型 回顾性队列研究 内科学 阶段(地层学) 肝癌 胃肠病学 并发症 外科 切除术 置信区间 古生物学 生物
作者
Kunyuan Jiang,Jingfei Li,Zihao Liu,Miao Chen,Wei Cai,Lianxin Liu,Dalong Yin
出处
期刊:International Journal of Surgery [Wolters Kluwer]
标识
DOI:10.1097/js9.0000000000001879
摘要

Objective: Patients with hepatocellular carcinoma (HCC) who undergo curative hepatectomy may experience varying remnant liver volumes. Our study aimed to evaluate whether the extent of liver resection has an effect on postoperative recurrence in HCC patients at China Liver Cancer Staging (CNLC) Ib stage. Methods: A retrospective analysis was conducted on 197 patients who underwent hepatectomy for a solitary HCC lesion measuring ≥5 cm (CNLC Ιb stage) between January 2019 and June 2022. Patients were divided into major hepatectomy (MAH) group (n=70) and minor hepatectomy (MIH) group (n=127) based on the extent of liver resection. Recurrence-free survival (RFS) was compared between the two groups. Propensity score matching (PSM) was employed to minimize bias in the retrospective analysis. Results: Patients who underwent MAH had a greater total complication rate than did those who underwent MIH (35.7% vs. 11.8%, P <0.001). The median RFS was 14.6 months (95% CI: 11.1-18.1) for MAH group and 24.1 months (95% CI 21.2-27.1) for MIH group ( P <0.001). After PSM, patients who underwent MAH still had a greater total complication rate than those who underwent MIH (36.7% vs. 16.3%, P =0.037). The median RFS was 13.2 months (95% CI: 15.1-21.7) for MAH group and 22.3 months (95% CI 18.1-26.5) for MIH group ( P =0.0013). The Cox regression model identified MAH as an independent poor predictor for HCC recurrence (hazard ratios of 1.826 and 2.062 before and after PSM, respectively; both P <0.05). Conclusion: MIH can be performed with fewer postoperative complications and contributes to improved RFS in patients with HCC at CNLC Ιb stage compared to MAH. Parenchyma-sparing resection should be considered the first choice for these HCCs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
yoyo完成签到,获得积分10
1秒前
亦犹未进完成签到,获得积分10
1秒前
wangxiaobin完成签到 ,获得积分10
2秒前
平淡凡柔发布了新的文献求助10
2秒前
3秒前
wxiao完成签到,获得积分10
4秒前
CHEN__02_发布了新的文献求助10
4秒前
英姑应助无糖乐采纳,获得10
5秒前
学习使我快乐1917完成签到,获得积分10
6秒前
llly发布了新的文献求助10
6秒前
7秒前
无花果应助Amai采纳,获得30
7秒前
huoyan2006应助平淡凡柔采纳,获得10
8秒前
9秒前
10秒前
Obsession发布了新的文献求助10
12秒前
junxing完成签到,获得积分10
14秒前
CHEN__02_完成签到,获得积分10
15秒前
852应助燕燕于飞采纳,获得10
15秒前
刘一三完成签到 ,获得积分10
16秒前
万能图书馆应助guozizi采纳,获得10
16秒前
xiaoting应助友好凡霜采纳,获得30
17秒前
奋斗慕凝完成签到 ,获得积分10
17秒前
17秒前
Ava应助Wl0115采纳,获得10
17秒前
17秒前
19秒前
gdh发布了新的文献求助10
21秒前
BCS完成签到,获得积分10
22秒前
22秒前
小牧鱼完成签到,获得积分10
22秒前
朱心怡发布了新的文献求助10
22秒前
李健应助科研通管家采纳,获得10
23秒前
科研通AI2S应助科研通管家采纳,获得10
23秒前
qiqi77ya应助科研通管家采纳,获得10
24秒前
斯文败类应助科研通管家采纳,获得10
24秒前
YSHZ发布了新的文献求助10
25秒前
huoyan2006应助Rando采纳,获得10
28秒前
29秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969574
求助须知:如何正确求助?哪些是违规求助? 3514435
关于积分的说明 11173986
捐赠科研通 3249755
什么是DOI,文献DOI怎么找? 1794979
邀请新用户注册赠送积分活动 875537
科研通“疑难数据库(出版商)”最低求助积分说明 804844