某种肠道细菌
阿克曼西亚
肠道菌群
认知障碍
糖尿病
医学
内分泌学
生物
内科学
认知
神经科学
免疫学
生物化学
乳酸菌
发酵
作者
Yage Du,Yu An,Ying Song,Nan Li,Jie Zheng,Yanhui Lu
标识
DOI:10.1016/j.expneurol.2024.114823
摘要
The established role of disturbances in the microbiota-gut-brain axis in the development of diabetic cognitive impairment (DCI) has long been recognized. It has shown the potential of Akkermansia muciniphila (A. muciniphila) in improving metabolic disorders and exerting anti-inflammatory effects. However, there remains a lack of comprehensive understanding regarding the specific effects and mechanisms underlying the treatment of DCI with A. muciniphila. This study aimed to evaluate the potential of A. muciniphila in alleviating DCI in db/db mice. Eleven-week-old db/db mice were administered either live or pasteurized A. muciniphila (5 × 10
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