Abstract 4137169: Artificial Intelligence-Enabled Electrocardiography For The Prediction of Future Type 2 Diabetes Mellitus

医学 心电图 糖尿病 心脏病学 内科学 2型糖尿病 内分泌学
作者
Libor Pastika,Konstantinos Patlatzoglou,Ewa Sieliwończyk,Joseph Barker,Boroumand Zeidaabadi,Kathryn A. McGurk,Sadia Khan,Danilo P. Mandic,James S. Ware,Nicholas S. Peters,Daniel B. Kramer,Jonathan W. Waks,Arunashis Sau,Fu Siong Ng
出处
期刊:Circulation [Lippincott Williams & Wilkins]
卷期号:150 (Suppl_1)
标识
DOI:10.1161/circ.150.suppl_1.4137169
摘要

Background: Undiagnosed diabetes and prediabetes present a significant global health challenge. Artificial Intelligence-enabled electrocardiography (AI-ECG) has shown promise in identifying subtle ECG changes in a wide range of subclinical diseases. Opportunistic ECG screening could identify prediabetic patients, enabling early interventions to prevent T2DM and adverse cardiovascular events. Aims: To develop the AI-ECG Risk Estimator to diagnose prevalent T2DM and predict future T2DM (AIRE-DM) Methods: AIRE-DM was trained on a real-world secondary care cohort from Beth Israel Deaconess Medical Center (BIDMC) of 1,163,401 ECGs and externally validated in the UK Biobank (UKB, N = 65,606). AIRE-DM employs a residual neural network architecture with a discrete-time survival loss function. Results: AIRE-DM accurately identifies prevalent T2DM (AUROC: BIDMC – 0.712 (0.705-0.719), UKB - 0.731 (0.725 - 0.741) and predicts future T2DM (C-index: BIDMC - 0.666 (0.658-0.675), UKB 0.689 (0.663-0.715). In subjects without T2DM, the high-risk quartile shows a markedly increased risk of future T2DM (HR: BIDMC - 4.67 (4.01-5.45), UKB - 10.10 (5.87-17.40), adjusted for age and sex. Adding AIRE-DM to clinical risk factors in BIDMC and to the American Diabetes Association (ADA) score in the UKB significantly enhanced predictive accuracy for future T2DM (C-index improvement: BIDMC - 0.0359 (0.0354-0.0363), UKB: 0.0337 (0.0324-0.0350), continuous net reclassification index: BIDMC - 0.407 (0.360-0.445), UKB - 0.391 (0.259-0.503)). Using phenome- and genome-wide association studies, we identified biologically plausible associations for AIRE-DM, including glucose regulation, cardiac morphology, diastolic dysfunction, arterial stiffness and lipid metabolism. We identified variants adjacent to CASQ2 , TBX3 , NOS1AP , TKT , VGLL2 and PRDM6 , which are known regulators of cardiac morphology, arterial stiffness and glucose metabolism. Conclusion: AIRE-DM can predict future T2DM in non-diabetics and enhances T2DM risk prediction when integrated with clinical risk scores. Its application holds promise for early identification of individuals at high risk of T2DM, enabling early lifestyle and pharmacological interventions.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
master-f完成签到 ,获得积分10
1秒前
1秒前
652183758完成签到 ,获得积分10
3秒前
sailingluwl完成签到,获得积分10
3秒前
端庄半凡完成签到 ,获得积分10
8秒前
权小夏完成签到 ,获得积分10
16秒前
study00122完成签到,获得积分10
17秒前
CC完成签到,获得积分10
18秒前
苗苗043完成签到 ,获得积分10
21秒前
您好刘皇叔完成签到,获得积分0
25秒前
Wu完成签到 ,获得积分10
26秒前
34秒前
serenity711完成签到 ,获得积分10
34秒前
优雅莞完成签到,获得积分10
34秒前
37秒前
CrsCrsCrs完成签到,获得积分10
38秒前
高速旋转老沁完成签到 ,获得积分10
40秒前
舒心威发布了新的文献求助10
41秒前
juice完成签到 ,获得积分10
47秒前
哎呀完成签到 ,获得积分10
48秒前
哭泣的缘郡完成签到 ,获得积分10
51秒前
51秒前
舒心威完成签到,获得积分10
55秒前
Bryan应助科研通管家采纳,获得10
57秒前
Bryan应助科研通管家采纳,获得10
57秒前
天天快乐应助阿宛采纳,获得10
58秒前
Nick爱学习发布了新的文献求助10
58秒前
冷傲菠萝完成签到 ,获得积分10
58秒前
四月完成签到 ,获得积分10
59秒前
广阔天地完成签到 ,获得积分10
1分钟前
笨笨青筠完成签到 ,获得积分10
1分钟前
KLED完成签到 ,获得积分10
1分钟前
zoe完成签到 ,获得积分10
1分钟前
Nick爱学习完成签到,获得积分10
1分钟前
cistronic完成签到,获得积分10
1分钟前
青子完成签到,获得积分10
1分钟前
ljy2015完成签到 ,获得积分10
1分钟前
蔡翌文完成签到 ,获得积分10
1分钟前
阿柴_Htao完成签到 ,获得积分10
1分钟前
gyx完成签到 ,获得积分10
1分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 2390
A new approach to the extrapolation of accelerated life test data 1000
Problems of point-blast theory 400
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4001381
求助须知:如何正确求助?哪些是违规求助? 3540765
关于积分的说明 11278689
捐赠科研通 3278680
什么是DOI,文献DOI怎么找? 1808154
邀请新用户注册赠送积分活动 884376
科研通“疑难数据库(出版商)”最低求助积分说明 810291