Relation between vitamin D deficiency and Pseudomonas aeruginosa colonization in patients with bronchiectasis

医学 铜绿假单胞菌 支气管扩张 殖民地化 微生物学 免疫学 内科学 细菌 遗传学 生物
作者
Yaoshen Wen,Ruoxuan Dai,Heng Yang,Jielu Lin,Rujia Tao,Ling Yang,Jin‐Fu Xu,Hai‐Wen Lu
出处
期刊:BMC Pulmonary Medicine [BioMed Central]
卷期号:25 (1)
标识
DOI:10.1186/s12890-025-03548-6
摘要

The relationship between vitamin D deficiency and Pseudomonas aeruginosa (P. aeruginosa) colonization in bronchiectasis patients is not well understood. This study was conducted at Shanghai Pulmonary Hospital from June 2014 to May 2018. Serum 25-hydroxyvitamin D levels were measured in patients with bronchiectasis, and clinical data including sputum culture results were collected. To investigate the relationship between vitamin D levels and P. aeruginosa colonization, we conducted correlation analysis and logistic regression. Additionally, in vitro experiments with bone marrow-derived macrophages (BMDMs) infected with P. aeruginosa strain PAO1 were performed to further explore the influence of vitamin D on the bacterial infection and inflammatory response. Among the 195 patients with bronchiectasis, 83.1% (162/195) were vitamin D deficient. A significant negative correlation was observed between serum vitamin D levels and the BSI (Bronchiectasis Severity Index) score. Patients with vitamin D deficiency showed higher rates of P. aeruginosa colonization compared to those with adequate vitamin D levels. Female gender and vitamin D deficiency were identified as risk factors for P. aeruginosa colonization in patients with bronchiectasis. Additionally, serum interleukin (IL)-1β levels were significantly elevated in the vitamin D-deficiency group. In vitro experiments, 1,25-dihydroxyvitamin D [1,25D] was shown to inhibit PAO1 phagocytosis in BMDMs and to suppress IL-1β secretion. Vitamin D deficiency was strongly associated with an increased risk of P. aeruginosa colonization in patients with bronchiectasis. Furthermore, vitamin D demonstrated protective effects by reducing P. aeruginosa survival in cells and modulating the inflammatory dysregulation induced by the bacterium.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
xiaojian_291发布了新的文献求助10
1秒前
3秒前
zho关闭了zho文献求助
4秒前
朴实的绿柳完成签到,获得积分10
4秒前
5秒前
wanci应助海风采纳,获得10
5秒前
英勇笑萍完成签到,获得积分10
5秒前
GIA完成签到,获得积分10
6秒前
神奇小鹿完成签到 ,获得积分10
7秒前
超级小飞侠完成签到 ,获得积分10
7秒前
彩色映雁发布了新的文献求助20
7秒前
粟粟完成签到,获得积分10
8秒前
认真的恶天完成签到,获得积分10
8秒前
8秒前
zyq发布了新的文献求助10
11秒前
shain完成签到,获得积分10
11秒前
zho关闭了zho文献求助
12秒前
13秒前
14秒前
fzhou完成签到 ,获得积分10
14秒前
勤恳易真发布了新的文献求助10
14秒前
迷路的八宝粥完成签到,获得积分10
15秒前
17秒前
汉堡包应助Xwu采纳,获得10
17秒前
悦悦大王发布了新的文献求助10
18秒前
NARUTO完成签到 ,获得积分10
18秒前
18秒前
轻松怜菡发布了新的文献求助10
18秒前
xmhxpz发布了新的文献求助10
19秒前
香草山完成签到 ,获得积分10
20秒前
小宋完成签到,获得积分10
21秒前
思维隋发布了新的文献求助10
21秒前
zho关闭了zho文献求助
22秒前
baibai发布了新的文献求助10
24秒前
sanwan发布了新的文献求助10
24秒前
25秒前
Allen驳回了Liufgui应助
28秒前
29秒前
yx_cheng应助悦悦大王采纳,获得10
30秒前
zho关闭了zho文献求助
30秒前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
Problems of point-blast theory 400
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Novel Preparation of Chitin Nanocrystals by H2SO4 and H3PO4 Hydrolysis Followed by High-Pressure Water Jet Treatments 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3998986
求助须知:如何正确求助?哪些是违规求助? 3538486
关于积分的说明 11274314
捐赠科研通 3277378
什么是DOI,文献DOI怎么找? 1807541
邀请新用户注册赠送积分活动 883909
科研通“疑难数据库(出版商)”最低求助积分说明 810080