Postoperative vasoplegia in lung transplantation: incidence and relation to outcome in a single-centre retrospective study

医学 肺移植 移植 内科学 肾脏替代疗法 肾功能 单中心 肾移植 心脏病学 外科 胃肠病学
作者
Alessandra Verzelloni Sef,Clarissa Ng Yin Ling,Tuan C. Aw,Rosalba Romano,Oliviero Crescenzi,V. Manikavasagar,A. Simón,Eric E. C. de Waal,Louit Thakuria,Anna Reed,Nándor Marczin
出处
期刊:BJA: British Journal of Anaesthesia [Elsevier BV]
卷期号:130 (6): 666-676 被引量:3
标识
DOI:10.1016/j.bja.2023.01.027
摘要

Background The incidence and clinical importance of vasoplegia after lung transplantation remains poorly studied. We describe the incidence of vasoplegia and its association with complications after lung transplantation. Methods Perioperative data of 279 lung transplant recipients operated on from 2015 to 2020 in a UK hospital were analysed retrospectively. Results Vasoplegia occurred in 41.6% of patients after lung transplantation (mild, 31.0%; moderate, 55.2%; severe, 13.8%). Compared with non-vasoplegic patients, vasoplegic patients had a higher incidence of any acute kidney injury, defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria (78.5% vs 65%, P=0.015), renal replacement therapy (47.4% vs 24.5%, P<0.001), and delayed chest closure (18.4% vs 9.2%, P=0.025); were ventilated longer (70 [32–368] vs 34 [19–105] h, P<0.001); and stayed longer in the ICU (12.9 [5–30] vs 6.8 [3–20] days, P<0.001). Mortality at 30 days and 1 yr was higher in patients with vasoplegia (11.2% vs 5.5% and 20.7% vs 11.7%, P=0.039, respectively). Severe vasoplegia represented a predictor of longer-term mortality (hazard ratio=1.65, P=0.008). Underlying infectious disease, increased BMI, higher preoperative pulmonary artery systolic pressure and bilirubin levels, lower glomerular filtration rate, and increased fresh frozen plasma transfusion were predictors of vasoplegia severity. Neutrophilia, leucocytosis, and increased C-reactive protein were associated with vasoplegia, but release of the neutrophil activation markers myeloperoxidase and heparin-binding protein was similar between groups. Conclusions Influenced by preoperative status as well as procedural factors and inflammatory response, vasoplegia is a common and critical condition after lung transplantation with worse short-term outcomes and long-term survival.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
吹吹蒲公英完成签到,获得积分10
刚刚
感动煎饼发布了新的文献求助10
1秒前
张婷婷完成签到,获得积分10
1秒前
路飞应助科研通管家采纳,获得10
2秒前
NexusExplorer应助科研通管家采纳,获得10
2秒前
kingwill应助科研通管家采纳,获得20
2秒前
2秒前
研友_VZG7GZ应助科研通管家采纳,获得10
2秒前
醒醒应助科研通管家采纳,获得10
2秒前
wu8577应助科研通管家采纳,获得10
2秒前
搜集达人应助科研通管家采纳,获得30
3秒前
共享精神应助科研通管家采纳,获得10
3秒前
a31256246511发布了新的文献求助10
3秒前
彭于晏应助科研通管家采纳,获得10
3秒前
Singularity应助科研通管家采纳,获得10
3秒前
3秒前
杨科研发布了新的文献求助10
3秒前
小蘑菇应助科研通管家采纳,获得10
3秒前
刻苦的舞仙完成签到,获得积分10
3秒前
3秒前
Singularity应助科研通管家采纳,获得10
3秒前
4秒前
4秒前
天天快乐应助科研通管家采纳,获得10
4秒前
英姑应助sundog采纳,获得10
4秒前
深情安青应助科研通管家采纳,获得10
4秒前
Singularity应助科研通管家采纳,获得10
4秒前
所所应助科研通管家采纳,获得10
4秒前
可爱小铭完成签到,获得积分10
4秒前
zhan应助科研通管家采纳,获得20
4秒前
wu8577应助科研通管家采纳,获得30
4秒前
爆米花应助科研通管家采纳,获得10
4秒前
Owen应助sdl采纳,获得10
5秒前
CipherSage应助科研通管家采纳,获得10
5秒前
大个应助科研通管家采纳,获得10
5秒前
Singularity应助科研通管家采纳,获得10
5秒前
仙都丽娜应助科研通管家采纳,获得30
5秒前
CodeCraft应助科研通管家采纳,获得10
5秒前
英姑应助科研通管家采纳,获得10
5秒前
高分求助中
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Cognitive Neuroscience: The Biology of the Mind (Sixth Edition) 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 588
Christian Women in Chinese Society: The Anglican Story 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3961589
求助须知:如何正确求助?哪些是违规求助? 3507917
关于积分的说明 11138698
捐赠科研通 3240341
什么是DOI,文献DOI怎么找? 1790929
邀请新用户注册赠送积分活动 872649
科研通“疑难数据库(出版商)”最低求助积分说明 803306