色谱法
醋酸铵
降级(电信)
乙腈
化学
相对标准差
洗必泰
高效液相色谱法
缓冲器(光纤)
相(物质)
检出限
有机化学
计算机科学
医学
电信
牙科
作者
William H. Doub,Don D Ruhl,Brad Hart,Paul R Mehelic,Larry K. Revelle
出处
期刊:PubMed
日期:1996-05-01
卷期号:79 (3): 636-9
被引量:13
摘要
A liquid chromatographic method was developed for determination of chlorhexidine and its degradation products in unformulated drug substance. A nonlinear gradient from 80% 0.1M ammonium acetate buffer, pH 5.0, to 20% buffer over 90 min (balance is acetonitrile) is applied to a 3 microns octadecylsilane bonded-phase column. The drug and some of its degradation products are determined at 230 nm. Of 11 previously identified degradation products, 9 are determined with good precision (relative standard deviation of peak area is < 2%).
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