Macular Degeneration: Wet-AMD on a Chip: Modeling Outer Blood-Retinal Barrier In Vitro (Adv. Healthcare Mater. 2/2018)

In article number 1700028, Noo Li Jeon, Jeong Hun Kim, and co-workers describe a unique organotypic eye-on-a-chip model that mimics the retinal pigment epithelium (RPE)–choroid complex in vitro. This model consists of an RPE monolayer and adjacent perfusable blood vessel network, which is supporting barrier function of the outer blood retinal barrier (oBRB). The intact barrier function of the RPE-choroid complex is reconstituted while maintaining important structural features.