Abstract 5848: Fucoidan adminstration attenuates radiation pneumonitis and fibrosis through reducing inflammatory cytokine expression in lung tissue

Abstract Purpose: There is no well-known compound to prevent radiation pneumonitis (RP) or prophylactically use to attenuate the toxicity of RP. RP is one of major complications in chest part irradiation and limitations of radiation dose. Fucoidan is a sulfated polysaccharide found mainly in various species of brown algae and brown seaweed. Recent studies have demonstrated its anti-inflammation effect. Since RP is an radiation induced inflammatory and fibrosis related complication, we investigated the effect of fucoidan adminstration on radiation pneumonitis and fibrosis. Materials and Methods: In this study, we compared the pneumonitis and fibrosis in lung tissue specimen between the lungs irradiated (10Gy/one shot) C57BL/6 mice with or without Fucoidan adminstration (200mg/kg /day, oral gavage for 14 days). Results: The results demonstrated that fucoidan adminstration attenuates pneumonitis and fibrosis in lung tissue. We found the accumulation of neutrophils in irradiated lung tissue was decreased, and the radiation induced Masson trichrome staining fibrosis was decreased. We also investigate the inflammatory -cytokine profiles in the irradiated lung tissue by protein array. The results revealed that fucoidan adminstration changes the inflammatory -cytokine expression pattern in in the irradiated lung tissue. Conclusions: This study demonstrated that inflammatory -cytokine expression after whole lung irradiation is correlated with neutrophil accumulation and radiation induced fibrosis. Interestingly, Fucoidan adminstration changes the inflammatory -cytokine expression pattern which may lead to attenuates radiation pneumonitis and fibrosis. It is potential to be a therapeutic molecular to attenuate or prevent radiation pneumonitis. Note: This abstract was not presented at the meeting. Citation Format: Szu-Yuan Wu. Fucoidan adminstration attenuates radiation pneumonitis and fibrosis through reducing inflammatory cytokine expression in lung tissue [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5848. doi:10.1158/1538-7445.AM2017-5848