Iron‐Mediated Azidomethylation or Azidotrideuteromethylation of Active Alkenes with Azidotrimethylsilane and Dimethyl Sulfoxide

Abstract A radical azidomethylation of various alkenes with azidotrimethylsilane and dimethyl sulfoxide has been achieved under mild reaction conditions, and the method efficiently introduces common and valuable azide and methyl groups into organic compounds. It offers a convenient method for preparing organic azides, which can be easily transformed into related amine derivatives and N ‐heterocycles. Control experiments such as capturing of the intermediate and gram‐scale reactions of the developed system as well as further transformations of the products of the reaction are presented. And a free radical is involved in the reaction process. magnified image