Comparison of post-anesthesia delirium in elderly patients treated with dexmedetomidine and midazolam maleate after thoracic surgery

右美托咪定 医学 麻醉 咪唑安定 谵妄 芬太尼 统计显著性 外科 心胸外科 镇静 内科学 重症监护医学
作者
Dongnan Yu,Yi Zhu,Jue Ma,Qiang Sun
出处
期刊:Biomedical Research-tokyo 卷期号:28 (15): 6852-6855 被引量:11
摘要

Objective: This study compared the post-anesthesia delirium in elderly patients treated with Dexmedetomidine and Midazolam Maleate after thoracic surgery. Methods: A total of 92 elderly patients treated with thoracic surgery in our hospital from June to September 2015 were selected. Digital random method was used to equally divide them into group A (n=46) and group B (n=46). Both groups were given with a continuous intravenous pumping of fentanyl for analgesia. Dexmedetomidine for group A and Midazolam Maleate for group B, and the delirium occurrence rates of patients in the two groups after the surgery were compared. Results: Awaking time 4.92 ± 1.18 min, breathing recovery time 10.53 ± 2.25 min, and extubation time 11.36 ± 2.63 min of patients in group A were significantly shorter than those in group B (P 0.05). The MMSE scores 27.01 ± 0.46, 27.22 ± 0 .50, 27.73 ± 0.54 and 28.62 ± 0.63 of patients in group A and 6 h and 1, 2 and 3 d after the surgery were significantly higher than those in the control group, and comparative difference between the two groups had statistical significance (P 0.05). Conclusion: Dexmedetomidine can improve the postoperative cognitive functions of elderly patients treated with thoracic surgery and reduce postoperative delirium.
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