核糖体
翻译(生物学)
蛋白质生物合成
细胞生物学
计算生物学
生物
信使核糖核酸
化学
遗传学
核糖核酸
基因
作者
Onn Brandman,Ramanujan S. Hegde
摘要
A comprehensive review of the discovery and molecular dissection of the eukaryotic ribosome-associated quality-control pathway for degradation of nascent proteins arising from interrupted translation. Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA, insufficient availability of charged tRNAs and genetic errors. All organisms have evolved mechanisms to recognize stalled ribosomes and initiate pathways for recycling, quality control and stress signaling. Here we review the discovery and molecular dissection of the eukaryotic ribosome-associated quality-control pathway for degradation of nascent polypeptides arising from interrupted translation.
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