Kidney Stones and Subclinical Atherosclerosis in Young Adults: The CARDIA Study

No AccessJournal of UrologyAdult Urology1 Mar 2011Kidney Stones and Subclinical Atherosclerosis in Young Adults: The CARDIA Study Alexander P. Reiner, Arnold Kahn, Brian H. Eisner, Mark J. Pletcher, Natalia Sadetsky, O. Dale Williams, Joseph F. Polak, David R. Jacobs, and Marshall L. Stoller Alexander P. ReinerAlexander P. Reiner Departments of Epidemiology, University of Washington, Seattle, Washington Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington More articles by this author , Arnold KahnArnold Kahn California Pacific Medical Center Research Institute, San Francisco, California More articles by this author , Brian H. EisnerBrian H. Eisner Department of Urology, Massachusetts General Hospital, Boston, Massachusetts Financial interest and/or other relationship with Boston Scientific Corporation, PercSys and the Ravine Group. More articles by this author , Mark J. PletcherMark J. Pletcher Departments of Urology and Medicine, University of California–San Francisco, San Francisco, California More articles by this author , Natalia SadetskyNatalia Sadetsky Departments of Urology and Medicine, University of California–San Francisco, San Francisco, California More articles by this author , O. Dale WilliamsO. Dale Williams Department of Medicine, University of Alabama, Birmingham, Alabama More articles by this author , Joseph F. PolakJoseph F. Polak Department of Radiology, Tufts-New England Medical Center, Boston, Massachusetts More articles by this author , David R. JacobsDavid R. Jacobs Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota More articles by this author , and Marshall L. StollerMarshall L. Stoller Departments of Urology and Medicine, University of California–San Francisco, San Francisco, California More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.10.086AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Recent reports suggest that nephrolithiasis and atherosclerosis share a number of risk factors. To our knowledge there has been no previous examination of the relationship between kidney stones and subclinical atherosclerotic disease. We studied the relationship between nephrolithiasis, and carotid wall thickness and carotid stenosis assessed by B-mode ultrasound in the general community using data from the CARDIA study. Materials and Methods: The CARDIA study is a United States, population based, observational study of 5,115 white and African-American men and women between the ages of 18 and 30 years at recruitment in 1985 to 1986. Results: By the year 20 examination 200 (3.9%) CARDIA participants had reported ever having kidney stones. Symptomatic kidney stones were associated with greater carotid wall thickness measured at the year 20 examination, particularly of the internal carotid/bulb region. Using a composite dichotomous end point of carotid stenosis and/or the upper quartile of internal carotid/bulb wall thickness, the association of kidney stones with carotid atherosclerosis was significant (OR 1.6, 95% CI 1.1–2.3, p = 0.01), even after adjusting for major atherosclerotic risk factors. Conclusions: The association between a history of kidney stones and subclinical carotid atherosclerosis in young adults adds further support to the notion that nephrolithiasis and atherosclerosis share common systemic risk factors and/or pathophysiology. References 1 : Urologic Diseases in America Project: urolithiasis. J Urol2005; 173: 848. 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Google Scholar © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byAssimos D (2019) Re: Urinary Proteomics Reveals Association between Pediatric Nephrolithiasis and Cardiovascular DiseaseJournal of Urology, VOL. 201, NO. 2, (224-224), Online publication date: 1-Feb-2019.Griebling T (2019) Re: Urolithiasis is Associated with an Increased Risk of Stroke: A Population-Based 5-Year Follow-up StudyJournal of Urology, VOL. 202, NO. 1, (8-8), Online publication date: 1-Jul-2019.Assimos D (2019) Re: Systemic Succinate Homeostasis and Local Succinate Signaling Affect Blood Pressure and Modify Risks for Calcium Oxalate LithogenesisJournal of Urology, VOL. 202, NO. 2, (203-204), Online publication date: 1-Aug-2019.Assimos D (2019) Re: Evaluation of Inactive Matrix-Gla-Protein (MGP) as a Biomarker for Incident and Recurrent Kidney StonesJournal of Urology, VOL. 202, NO. 6, (1092-1092), Online publication date: 1-Dec-2019.Assimos D (2018) Re: Vascular Disease and Kidney Stones: Abdominal Aortic Calcifications are Associated with Low Urine pH and HypocitraturiaJournal of Urology, VOL. 198, NO. 6, (1203-1204), Online publication date: 1-Dec-2017.Hsi R, Spieker A, Stoller M, Jacobs D, Reiner A, McClelland R, Kahn A, Chi T, Szklo M and Sorensen M (2015) Coronary Artery Calcium Score and Association with Recurrent Nephrolithiasis: The Multi-Ethnic Study of AtherosclerosisJournal of Urology, VOL. 195, NO. 4 Part 1, (971-976), Online publication date: 1-Apr-2016.Assimos D (2018) Re: Vascular Calcification and Bone Mineral Density in Recurrent Kidney Stone FormersJournal of Urology, VOL. 194, NO. 4, (1015-1015), Online publication date: 1-Oct-2015.Assimos D (2018) Re: History of Kidney Stones and the Risk of Coronary Heart DiseaseJournal of Urology, VOL. 191, NO. 3, (678-680), Online publication date: 1-Mar-2014.Sorensen M, Kahn A, Reiner A, Tseng T, Shikany J, Wallace R, Chi T, Wactawski-Wende J, Jackson R, O'Sullivan M, Sadetsky N and Stoller M (2018) Impact of Nutritional Factors on Incident Kidney Stone Formation: A Report From the WHI OSJournal of Urology, VOL. 187, NO. 5, (1645-1650), Online publication date: 1-May-2012. Volume 185Issue 3March 2011Page: 920-925 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.KeywordsurolithiasisatherosclerosisMetricsAuthor Information Alexander P. Reiner Departments of Epidemiology, University of Washington, Seattle, Washington Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington More articles by this author Arnold Kahn California Pacific Medical Center Research Institute, San Francisco, California More articles by this author Brian H. Eisner Department of Urology, Massachusetts General Hospital, Boston, Massachusetts Financial interest and/or other relationship with Boston Scientific Corporation, PercSys and the Ravine Group. More articles by this author Mark J. Pletcher Departments of Urology and Medicine, University of California–San Francisco, San Francisco, California More articles by this author Natalia Sadetsky Departments of Urology and Medicine, University of California–San Francisco, San Francisco, California More articles by this author O. Dale Williams Department of Medicine, University of Alabama, Birmingham, Alabama More articles by this author Joseph F. Polak Department of Radiology, Tufts-New England Medical Center, Boston, Massachusetts More articles by this author David R. Jacobs Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota More articles by this author Marshall L. Stoller Departments of Urology and Medicine, University of California–San Francisco, San Francisco, California More articles by this author Expand All Advertisement PDF downloadLoading ...