泛素
炎症
泛素蛋白连接酶类
泛素连接酶
发病机制
药物开发
生物信息学
生物
免疫学
细胞生物学
医学
药品
药理学
遗传学
基因
作者
Santosh Kumar Goru,Anuradha Pandey,Anil Bhanudas Gaikwad
标识
DOI:10.1016/j.phrs.2016.02.006
摘要
Ubiquitination is one of the post translational modifications which decide the fate of various proteins in the cells, by either directing them towards proteasomal degradation or participation in several cell signalling pathways. Recently, the role of ubiquitination has been unravelled in pathogenesis and progression of various diseases, where inflammation is critical, like obesity, insulin resistance, atherosclerosis, angiotensin-II induced cardiac inflammation and asthma. E3 ligases are known to be instrumental in regulation of the inflammatory cascade. This review focuses on the role of different E3 ligases in the development of inflammatory diseases and thus may help us to target these E3 ligases in future drug discovery to prevent inflammation.
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