质谱法
解吸电喷雾电离
化学
萃取电喷雾电离
质谱成像
环境电离
质谱
分析化学(期刊)
电喷雾电离
离子
电离
色谱法
质谱中的样品制备
化学电离
有机化学
作者
R. Graham Cooks,Zheng Ouyang,Zoltán Takáts,Justin M. Wiseman
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2006-03-16
卷期号:311 (5767): 1566-1570
被引量:1367
标识
DOI:10.1126/science.1119426
摘要
A recent innovation in mass spectrometry is the ability to record mass spectra on ordinary samples, in their native environment, without sample preparation or preseparation by creating ions outside the instrument. In desorption electrospray ionization (DESI), the principal method described here, electrically charged droplets are directed at the ambient object of interest; they release ions from the surface, which are then vacuumed through the air into a conventional mass spectrometer. Extremely rapid analysis is coupled with high sensitivity and high chemical specificity. These characteristics are advantageously applied to high-throughput metabolomics, explosives detection, natural products discovery, and biological tissue imaging, among other applications. Future possible uses of DESI for in vivo clinical analysis and its adaptation to portable mass spectrometers are described.
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