Relationship between Plasma Levels of Lipopolysaccharide (LPS) and LPS‐Binding Protein in Patients with Severe Sepsis and Septic Shock

四分位间距 败血症 感染性休克 医学 脂多糖 胃肠病学 内科学 脂多糖结合蛋白 休克(循环) 免疫学 急性期蛋白 炎症
作者
Steven M. Opal,Patrick J. Scannon,Jean‐Louis Vincent,Mark White,Stephen F. Carroll,John E. Palardy,Nicolas A. Parejo,John P. Pribble,Jon H. Lemke
出处
期刊:The Journal of Infectious Diseases [Oxford University Press]
卷期号:180 (5): 1584-1589 被引量:584
标识
DOI:10.1086/315093
摘要

Plasma endotoxin and lipopolysaccharide-binding protein (LBP) levels were measured in a group of 253 patients at the onset of severe sepsis and/or septic shock. Endotoxin levels were significantly greater than control levels (n = 33; mean ± SD, 5.1 ± 7.3, pg/mL) in 78.3% of patients. Median endotoxin levels in patients with sepsis were 300 pg/mL (25%–75% interquartile range, 110–726 pg/mL). LBP levels were elevated in 97% of patients compared with normal control values of 4.1 ± 1.65 µg/mL. Median LBP levels in patients with sepsis were 31.2 µg/mL (interquartile range, 22.5–47.7 µg/mL). Median endotoxin levels at study entry were more highly elevated (515 vs. 230 pg/mL; P < .01), and LBP levels were less highly elevated (28.0 vs. 33.2 µg/mL; P < .05) in nonsurvivors than survivors over the 28-day study period. No correlation was found between endotoxin and LBP levels. The quantitative level of both endotoxin and LBP may have prognostic significance in patients with severe sepsis.
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