Research progress on the relationship between IgE and autoimmune diseases

IgE is closely related to autoimmune diseases. On the one hand, a variety of autoimmune diseases found the increasing IgE. This IgE is just as allergen-specific IgE or IgE autoantibody is not yet clear. On the other hand, the pathogenic mechanism of IgE includes not only the direct damage due to immune complex deposition, activation of basophils and mast cells releasing inflammatory mediators, but also includes the autoimmune effects of type I interferons produced by plasma cell-like dendritic cells. This article expounds the relationship between IgE and the occurrence and development of several autoimmune diseases.(Chin J Lab Med, 2018, 41: 242-245) Key words: IgE; IgE autoantibodies; Autoimmune disease