Selective Radical N−H Activation: the Unprecedented Harnessing of Formamide with S8 for N−S−N Bonds Construction

Abstract A copper‐catalyzed novel, highly selective formamide (N−H) activation for the accessing broad range of formamide sulfides was developed. This strategy presented the first example on N−S−N bonds construction under mild conditions, featuring selective N‐radical based mechanism, as well as cheap, stable and environmentally friendly S 8 as source of sulfur. In particular, this process was well defined by DFT calculation and a leading product was found to have significant anti‐fungal activity.