生物
牛磺酸
殖民抵抗
微生物学
寄主(生物学)
病菌
殖民地化
生物化学
氨基酸
生态学
作者
Apollo Stacy,Vinícius Andrade‐Oliveira,John A. McCulloch,Benedikt Hild,Ji Hoon Oh,Paula Juliana Pérez‐Chaparro,Choon Kiat Sim,Ai Ing Lim,Verena M. Link,Michel Enamorado,Giorgio Trinchieri,Julia A. Segre,Barbara Rehermann,Yasmine Belkaid
出处
期刊:Cell
[Elsevier]
日期:2021-02-01
卷期号:184 (3): 615-627.e17
被引量:166
标识
DOI:10.1016/j.cell.2020.12.011
摘要
The microbiota shields the host against infections in a process known as colonization resistance. How infections themselves shape this fundamental process remains largely unknown. Here, we show that gut microbiota from previously infected hosts display enhanced resistance to infection. This long-term functional remodeling is associated with altered bile acid metabolism leading to the expansion of taxa that utilize the sulfonic acid taurine. Notably, supplying exogenous taurine alone is sufficient to induce this alteration in microbiota function and enhance resistance. Mechanistically, taurine potentiates the microbiota’s production of sulfide, an inhibitor of cellular respiration, which is key to host invasion by numerous pathogens. As such, pharmaceutical sequestration of sulfide perturbs the microbiota’s composition and promotes pathogen invasion. Together, this work reveals a process by which the host, triggered by infection, can deploy taurine as a nutrient to nourish and train the microbiota, promoting its resistance to subsequent infection.
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