已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Associations of Empagliflozin With Left Ventricular Volumes, Mass, and Function in Patients With Heart Failure and Reduced Ejection Fraction

医学 射血分数 恩帕吉菲 心脏病学 内科学 心力衰竭 安慰剂 心室重构 糖尿病 2型糖尿病 内分泌学 病理 替代医学
作者
Massar Omar,J. Steen Jensen,Mulham Ali,Peter Frederiksen,Caroline Kistorp,Lars Videbæk,Mikael Kjær Poulsen,Christian Tuxen,Søren Møller,Finn Gustafsson,Lars Køber,Morten Schou,Jacob Eifer Møller
出处
期刊:JAMA Cardiology [American Medical Association]
卷期号:6 (7): 836-836 被引量:136
标识
DOI:10.1001/jamacardio.2020.6827
摘要

Sodium-glucose cotransporter-2 inhibitors (SGLT2i) improve outcomes in patients with heart failure and a reduced ejection fraction (HFrEF). The association with cardiac remodeling has not been investigated.To investigate the outcome of the SGLT2i empagliflozin, compared with placebo, on cardiac remodeling in patients with HFrEF.This exploratory post hoc analysis included participants with stable HFrEF and ejection fractions of 40% or less, who were randomly enrolled in an investigator-initiated, multicenter, double-blind, placebo-controlled randomized clinical trial in Denmark. Enrollment commenced on June 29, 2017, and continued through September 10, 2019, with the last participant follow-up on December 20, 2019.Randomization (1:1) to empagliflozin (10 mg once daily) or matching placebo in addition to recommended heart failure therapy for 12 weeks.Efficacy measures were changes from baseline to week 12 in left ventricular end-systolic and end-diastolic volume indexes, left atrial volume index, and left ventricular ejection fraction adjusted for age, sex, type 2 diabetes, and atrial fibrillation. Secondary efficacy measures included changes in left ventricular mass index, global longitudinal strain, and relative wall thickness.A total of 190 patients were randomized (95 each receiving empagliflozin and placebo), with a mean (SD) age of 64 (11) years; 162 were men (85.3%), 97 (51.1%) had ischemic HFrEF, 24 (12.6%) had type 2 diabetes, and the mean (SD) latest recorded left ventricular ejection fraction was 29% (8%). Of the 190, 186 completed the study. Empagliflozin significantly reduced left ventricular end-systolic volume index (-4.3 [95% CI, -8.5 to -0.1] mL/m2; P = .04), left ventricular end-diastolic volume index (-5.5 [95% CI, -10.6 to -0.4] mL/m2; P = .03), and left atrial volume index (-2.5 [95% CI, -4.8 to -0.1] mL/m2; P = .04) compared with placebo at 12 weeks' follow-up, with no change in left ventricular ejection fraction (1.2% [95% CI, -1.2% to 3.6%]; P = .32). These findings were consistent across subgroups. Of secondary efficacy measures, left ventricular mass index was significantly reduced by empagliflozin (-9.0 [95% CI, -17.2 to -0.8] g/m2; P = .03).In this small, randomized, short-term study, empagliflozin was associated with modest reductions in left ventricular and left atrial volumes with no association with ejection fraction. Effects beyond 12 weeks of SGLT2i use require further study.ClinicalTrials.gov Identifier: NCT03198585.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
2秒前
笨笨的寄真完成签到 ,获得积分10
3秒前
Becky完成签到 ,获得积分10
3秒前
6秒前
零知识完成签到 ,获得积分10
6秒前
伽拉发布了新的文献求助10
12秒前
洸彦完成签到 ,获得积分10
14秒前
CipherSage应助G1997采纳,获得10
14秒前
Ethan完成签到 ,获得积分0
15秒前
15秒前
Rondab应助科研通管家采纳,获得10
16秒前
科研通AI2S应助科研通管家采纳,获得10
17秒前
17秒前
CipherSage应助科研通管家采纳,获得10
17秒前
Rondab应助科研通管家采纳,获得10
17秒前
Rondab应助科研通管家采纳,获得10
17秒前
SciGPT应助科研通管家采纳,获得10
17秒前
SciGPT应助科研通管家采纳,获得10
17秒前
17秒前
明钟达完成签到 ,获得积分10
20秒前
domingo发布了新的文献求助20
20秒前
HughWang完成签到,获得积分10
23秒前
嘟嘟豆806完成签到 ,获得积分10
25秒前
28秒前
火星完成签到 ,获得积分10
28秒前
30秒前
研友_Zlx3aZ发布了新的文献求助10
32秒前
认真的三问完成签到,获得积分20
34秒前
kyfbrahha完成签到 ,获得积分10
35秒前
35秒前
maleo发布了新的文献求助30
38秒前
domingo完成签到,获得积分10
39秒前
一直向前发布了新的文献求助10
39秒前
希望天下0贩的0应助Unicorn采纳,获得50
40秒前
toto完成签到 ,获得积分10
40秒前
宣灵薇完成签到,获得积分0
41秒前
41秒前
45秒前
大模型应助黎乐荷采纳,获得10
46秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989957
求助须知:如何正确求助?哪些是违规求助? 3532034
关于积分的说明 11256000
捐赠科研通 3270880
什么是DOI,文献DOI怎么找? 1805070
邀请新用户注册赠送积分活动 882252
科研通“疑难数据库(出版商)”最低求助积分说明 809216