乙酰胆碱
卡巴胆碱
神经科学
鸣鸟
胆碱能的
陈规定型
毒蕈碱乙酰胆碱受体
感觉系统
运动前皮质
心理学
生物
解剖
内分泌学
受体
刺激
背
古生物学
生物化学
多巴胺
安非他明
作者
Paul I. Jaffe,Michael S. Brainard
出处
期刊:eLife
[eLife Sciences Publications, Ltd.]
日期:2020-05-19
卷期号:9
被引量:23
摘要
Acetylcholine is well-understood to enhance cortical sensory responses and perceptual sensitivity in aroused or attentive states. Yet little is known about cholinergic influences on motor cortical regions. Here we use the quantifiable nature of birdsong to investigate how acetylcholine modulates the cortical (pallial) premotor nucleus HVC and shapes vocal output. We found that dialyzing the cholinergic agonist carbachol into HVC increased the pitch, amplitude, tempo and stereotypy of song, similar to the natural invigoration of song that occurs when males direct their songs to females. These carbachol-induced effects were associated with increased neural activity in HVC and occurred independently of basal ganglia circuitry. Moreover, we discovered that the normal invigoration of female-directed song was also accompanied by increased HVC activity and was attenuated by blocking muscarinic acetylcholine receptors. These results indicate that, analogous to its influence on sensory systems, acetylcholine can act directly on cortical premotor circuitry to adaptively shape behavior.
科研通智能强力驱动
Strongly Powered by AbleSci AI