免疫系统
抗体
抗原
免疫疗法
等离子体电池
肿瘤微环境
B-1电池
同型
B细胞
免疫学
T细胞
生物
抗原提呈细胞
癌症研究
单克隆抗体
作者
Г. В. Шаронов,Ekaterina O. Serebrovskaya,Diana V. Yuzhakova,Olga V. Britanova,Dmitriy M. Chudakov
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2020-01-27
卷期号:20 (5): 294-307
被引量:450
标识
DOI:10.1038/s41577-019-0257-x
摘要
Recent data show that B cells and plasma cells located in tumours or in tumour-draining lymph nodes can have important roles in shaping antitumour immune responses. In tumour-associated tertiary lymphoid structures, T cells and B cells interact and undergo cooperative selection, specialization and clonal expansion. Importantly, B cells can present cognate tumour-derived antigens to T cells, with the functional consequences of such interactions being shaped by the B cell phenotype. Furthermore, the isotype and specificity of the antibodies produced by plasma cells can drive distinct immune responses. Here we summarize our current knowledge of the roles of B cells and antibodies in the tumour microenvironment. Moreover, we discuss the potential of using immunoglobulin repertoires as a source of tumour-specific receptors for immunotherapy or as biomarkers to predict the efficacy of immunotherapeutic interventions.
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