亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Efficacy and safety of Finasteride (5 alpha-reductase inhibitor) monotherapy in patients with benign prostatic hyperplasia: A critical review of the literature

非那雄胺 医学 下尿路症状 不利影响 国际前列腺症状评分 泌尿科 坦索罗辛 随机对照试验 前列腺 临床试验 科克伦图书馆 良性前列腺增生(BPH) 杜他星 内科学 增生 癌症
作者
Gian Maria Busetto,Francesco Del Giudice,Daniele D’Agostino,Daniele Romagnoli,Andrea Minervini,Bernardo Rocco,Alessandro Antonelli,Antonio Celia,Riccardo Schiavina,Luca Cindolo,Benjamin I. Chung,Jae Heon Kim,Martina Maggi,Alessandro Sciarra,Ettore De Berardinis,Angelo Porreca
出处
期刊:Archivio italiano di urologia, andrologia [PAGEPress Publications]
卷期号:91 (4): 205-210 被引量:11
标识
DOI:10.4081/aiua.2019.4.205
摘要

Background: Combination therapy with 5 alpha-reductase inhibitor (5-ARI) and alpha-blocker can be considered as a gold standard intervention for medical management of lower urinary tract symptoms related to benign prostatic hyperplasia (LUTS/BPH). On the other hand, 5-ARI monotherapy and in particular Finasteride alone is currently getting focus of attention especially due to lack of systematic reviews investigating efficacy outcomes and/or adverse events associated. Objectives: Aim of the present critical review was to analyze current knowledge of clinical efficacy and incidence of adverse events associated with 5-ARI treatment for LUTS/BPH. Materials and methods: A systematic review of clinical trials of the literature of the past 20 years was performed using database from PubMed, Cochrane Collaboration and Embase. A total of 8821 patients were included in this study and inclusion criteria for studies selection were: data from randomized clinical trials (RCTs) focusing their attention on the clinical role of Finasteride monotherapy for symptomatic BPH. Parameters of research included prostate specific antigen (PSA), prostate volume (PV), International Prostate Symptom Score (IPPS), postvoid residual urine (PVR), voiding symptoms of IPSS (voiding IPSS), maximum urinary flow rate (Qmax), and adverse events (AEs). Results: Overall 12 original articles were included and critically evaluated. Sample sizes of patient actively treated with finasteride varied from 13 to 1524 cases analyzed in a single study. Follow-up after treatments ranged from 3 to 54 months. The effect of finasteride in reducing prostate volume (PV) was moderate (standardized mean difference (SMD) effect between 0.5 to 0.8 for all trials evaluable) while the effect on IPSS score and Qmax was considered significant (SMD in the 0.2 to 0.5 variation range). No severe AEs and/or psychiatric disorders were retrieved among the studies. Sexual health dysfunctions were significantly influenced by finasteride therapy when compared with placebo treated patients. Conclusions: Although significant clinical benefits of finasteride monotherapy were demonstrated, the effective size of the available reports included in the analysis is limited. Additional head-to-head studies would be needed to re-evaluate clinical efficacy and safety of 5-ARI in combination or not with alpha blockers.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
落后从阳完成签到 ,获得积分10
51秒前
2分钟前
瓜皮糖浆发布了新的文献求助30
2分钟前
港港完成签到 ,获得积分10
2分钟前
2分钟前
瓜皮糖浆完成签到,获得积分10
2分钟前
浅黑色饕餮完成签到,获得积分10
2分钟前
斯文败类应助浅黑色饕餮采纳,获得10
2分钟前
拜托你清醒一点完成签到 ,获得积分10
2分钟前
lelecha发布了新的文献求助10
3分钟前
3分钟前
zs完成签到 ,获得积分10
3分钟前
lelecha完成签到,获得积分10
3分钟前
3分钟前
风起云涌龙完成签到 ,获得积分0
4分钟前
bkagyin应助科研通管家采纳,获得10
5分钟前
mellow发布了新的文献求助10
5分钟前
Aloha完成签到 ,获得积分10
5分钟前
熊一只发布了新的文献求助10
6分钟前
nanfang完成签到 ,获得积分10
6分钟前
光亮的自行车完成签到 ,获得积分10
6分钟前
Qvby3完成签到 ,获得积分10
7分钟前
领导范儿应助科研通管家采纳,获得10
7分钟前
可爱的函函应助Jenaloe采纳,获得10
7分钟前
7分钟前
7分钟前
7分钟前
Jenaloe发布了新的文献求助10
7分钟前
Jenaloe完成签到,获得积分10
7分钟前
8分钟前
落后的西牛完成签到 ,获得积分10
8分钟前
Artin完成签到,获得积分10
8分钟前
深情安青应助科研通管家采纳,获得10
9分钟前
xzn发布了新的文献求助10
9分钟前
Rebeccaiscute完成签到 ,获得积分10
9分钟前
WANG发布了新的文献求助10
10分钟前
小王完成签到 ,获得积分10
10分钟前
12分钟前
林夏果发布了新的文献求助10
12分钟前
林夏果完成签到,获得积分10
12分钟前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
"Sixth plenary session of the Eighth Central Committee of the Communist Party of China" 400
Introduction to Modern Controls, with illustrations in MATLAB and Python 310
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3056457
求助须知:如何正确求助?哪些是违规求助? 2713069
关于积分的说明 7434540
捐赠科研通 2358102
什么是DOI,文献DOI怎么找? 1249268
科研通“疑难数据库(出版商)”最低求助积分说明 607010
版权声明 596195