Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability

心理干预 随机对照试验 物理疗法 生活质量(医疗保健) 日常生活活动 体力活动 独立生活
作者
Marco Pahor,Jack M. Guralnik,Stephen D. Anton,Walter T. Ambrosius,Steven N. Blair,Timothy S. Church,Mark A. Espeland,Roger A. Fielding,Thomas M. Gill,Nancy W. Glynn,Erik J. Groessl,Abby C. King,Stephen B. Kritchevsky,Todd M. Manini,Mary M. McDermott,Michael E. Miller,Anne B. Newman,Jeff D. Williamson
出处
期刊:Journal of the American Geriatrics Society [Wiley]
卷期号:68 (4): 872-881 被引量:11
标识
DOI:10.1111/jgs.16365
摘要

Background Walking independently is basic to human functioning. The Lifestyle Interventions and Independence for Elders (LIFE) studies were developed to assess whether initiating physical activity could prevent major mobility disability (MMD) in sedentary older adults. Methods We review the development and selected findings of the LIFE studies from 2000 through 2019, including the planning phase, the LIFE-Pilot Study, and the LIFE Study. Results The planning phase and the LIFE-Pilot provided key information for the successful implementation of the LIFE Study. The LIFE Study, involving 1635 participants randomized at eight sites throughout the United States, showed that compared with health education, the physical activity program reduced the risk of the primary outcome of MMD (inability to walk 400 m: hazard ratio = 0.82; 95% confidence interval = 0.69-0.98; P = .03), and that the intervention was cost-effective. There were no significant effects on cognitive outcomes, cardiovascular events, or serious fall injuries. In addition, the LIFE studies provided relevant findings on a broad range of other outcomes, including health, frailty, behavioral outcomes, biomarkers, and imaging. To date, the LIFE studies have generated a legacy of 109 peer-reviewed publications, 19 ancillary studies, and 38 independently funded grants and clinical trials, and advanced the development of 59 early career scientists. Data and biological samples of the LIFE Study are now publicly available from a repository sponsored by the National Institute on Aging (https://agingresearchbiobank.nia.nih.gov). Conclusions The LIFE studies generated a wealth of important scientific findings and accelerated research in geriatrics and gerontology, benefiting the research community, trainees, clinicians, policy makers, and the general public. J Am Geriatr Soc 68:872-881, 2020.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
wnan_07发布了新的文献求助10
刚刚
刚刚
由道之完成签到,获得积分0
1秒前
稀里糊涂图完成签到,获得积分10
2秒前
2秒前
12345完成签到,获得积分10
3秒前
5秒前
zzbyxh发布了新的文献求助10
5秒前
5秒前
精明的沅发布了新的文献求助10
5秒前
6秒前
Max哈哈哈发布了新的文献求助10
6秒前
没有昵称关注了科研通微信公众号
6秒前
7秒前
SUN完成签到,获得积分10
8秒前
今后应助Emma采纳,获得10
9秒前
baobao完成签到,获得积分10
10秒前
Sky发布了新的文献求助10
11秒前
11秒前
11秒前
MrDI发布了新的文献求助10
12秒前
13秒前
查理fofo发布了新的文献求助10
13秒前
活力青筠发布了新的文献求助10
14秒前
111发布了新的文献求助10
16秒前
墨客发布了新的文献求助10
16秒前
泡泡糖发布了新的文献求助10
19秒前
韩凡发布了新的文献求助10
21秒前
李奥发布了新的文献求助10
21秒前
量子星尘发布了新的文献求助10
21秒前
三物完成签到 ,获得积分10
21秒前
Seven发布了新的文献求助10
21秒前
21秒前
MrDI完成签到,获得积分10
22秒前
小魏不学无术完成签到,获得积分10
22秒前
Lucas应助冷酷的格尔曼采纳,获得10
24秒前
neWA完成签到,获得积分10
25秒前
Emma发布了新的文献求助10
25秒前
26秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975375
求助须知:如何正确求助?哪些是违规求助? 3519700
关于积分的说明 11199305
捐赠科研通 3256034
什么是DOI,文献DOI怎么找? 1798049
邀请新用户注册赠送积分活动 877386
科研通“疑难数据库(出版商)”最低求助积分说明 806305