Efficacy of shear-wave elastography versus dynamic optical breast imaging for predicting the pathological response to neoadjuvant chemotherapy in breast cancer

医学 乳腺癌 化疗 弹性成像 核医学 新辅助治疗 病态的 前瞻性队列研究 癌症 超声波 内科学 肿瘤科 放射科
作者
Jing Zhang,Xueying Tan,Xintong Zhang,Ye Kang,Jianyi Li,Weidong Ren,Yan Ma
出处
期刊:European Journal of Radiology [Elsevier BV]
卷期号:129: 109098-109098 被引量:10
标识
DOI:10.1016/j.ejrad.2020.109098
摘要

Purpose Explore the value of shear-wave elastography (SWE) parameters and dynamic optical breast imaging features for predicting pathological responses to neoadjuvant chemotherapy (NACT) in breast cancer (BC). Method This prospective cohort study included 91 BC patients receiving NACT. Tumor size, SWE (maximum stiffness [Emax] and mean stiffness [Emean]), blood score (BS), and oxygen score (OS) and their relative changes were collected before (t0), during (t1–t5), and after NACT (t6). The pathological response was classified according to the residual cancer burden. Relationships between tumor size, SWE stiffness, BS, and OS at t0–t6 were analyzed, and their predictive power was compared. Results During six NACT cycles, tumor size, tumor stiffness, and BS decreased, and tumor OS increased. ΔEmean (t2), E2mean, BS2, and OS2 had a greater power than other indexes for predicting a favorable response (AUC = 0.79, 0.71, 0.77, 0.78) and a resistance response (0.86, 0.74, 0.71, 0.71). For the favorable response, predictive power did not differ significantly between ΔEmean (t2), E2mean, BS2, and OS2, whereas for the resistance response, ΔEmean (t2) showed better prediction than E2mean, BS2, and OS2. Conclusions SWE stiffness, BS, and OS exhibited good and similar performances in predicting a NACT favorable response, and SWE stiffness showed better performance than BS and OS in predicting NACT resistance. These results may provide an important reference for individualized treatment in BC patients receiving NACT.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
lanjq兰坚强完成签到,获得积分10
刚刚
hjj完成签到,获得积分10
刚刚
笑点低一手完成签到,获得积分10
刚刚
李奥完成签到,获得积分10
刚刚
1秒前
111111完成签到,获得积分10
1秒前
昏睡的蟠桃应助abcdefj采纳,获得50
2秒前
研路漫漫完成签到,获得积分10
2秒前
胡文静完成签到,获得积分10
2秒前
2秒前
陈陈发布了新的文献求助10
2秒前
林子青完成签到,获得积分10
3秒前
3秒前
小广完成签到,获得积分10
4秒前
4秒前
whale完成签到,获得积分10
4秒前
4秒前
追寻依风应助小飞侠来咯采纳,获得10
4秒前
TianFuAI完成签到,获得积分10
5秒前
WSGQT发布了新的文献求助10
5秒前
wyw完成签到,获得积分10
5秒前
5秒前
汤圆发布了新的文献求助10
5秒前
sueeu完成签到,获得积分20
5秒前
SYLH应助飞快的寒香采纳,获得10
5秒前
6秒前
Hsia完成签到,获得积分10
7秒前
田様应助nano采纳,获得10
7秒前
7秒前
aoao嘉完成签到,获得积分10
7秒前
隐形曼青应助MY采纳,获得10
8秒前
小太阳完成签到,获得积分10
8秒前
醉玉颓山完成签到,获得积分10
8秒前
luo完成签到,获得积分10
8秒前
9秒前
9秒前
勤恳觅珍发布了新的文献求助10
9秒前
背后海亦完成签到,获得积分10
10秒前
三火完成签到,获得积分10
10秒前
10秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 2390
A new approach to the extrapolation of accelerated life test data 1000
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4009254
求助须知:如何正确求助?哪些是违规求助? 3549107
关于积分的说明 11300780
捐赠科研通 3283530
什么是DOI,文献DOI怎么找? 1810370
邀请新用户注册赠送积分活动 886168
科研通“疑难数据库(出版商)”最低求助积分说明 811267