自愈水凝胶
佩多:嘘
聚苯乙烯磺酸盐
药物输送
材料科学
控制释放
化学工程
药品
纳米技术
疏水效应
聚苯乙烯
聚合物
化学
高分子化学
有机化学
图层(电子)
药理学
复合材料
工程类
医学
作者
Anna Puiggalı́-Jou,Eric Cazorla,Guillem Ruano,Ismael Babeli,Maria‐Pau Ginebra,José García‐Torres,Carlos Alemán
标识
DOI:10.1021/acsbiomaterials.0c01400
摘要
Stimuli-responsive biomaterials have attracted significant attention for the construction of on-demand drug release systems. The possibility of using external stimulation to trigger drug release is particularly enticing for hydrophobic compounds, which are not easily released by simple diffusion. In this work, an electrochemically active hydrogel, which has been prepared by gelling a mixture of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) and alginate (Alg), has been loaded with curcumin (CUR), a hydrophobic drug with a wide spectrum of clinical applications. The PEDOT/Alg hydrogel is electrochemically active and organizes as segregated PEDOT- and Alg-rich domains, explaining its behavior as an electroresponsive drug delivery system. When loaded with CUR, the hydrogel demonstrates a controlled drug release upon application of a negative electrical voltage. Comparison with the release profiles obtained applying a positive voltage and in the absence of electrical stimuli indicates that the release mechanism dominating this system is complex because of not only the intermolecular interactions between the drug and the polymeric network but also the loading of a hydrophobic drug in a water-containing delivery system.
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