气凝胶
止血
纳米纤维
羧甲基纤维素
材料科学
羟乙基纤维素
生物相容性
生物医学工程
细菌纤维素
复合材料
纤维素
化学工程
化学
外科
医学
有机化学
钠
冶金
工程类
作者
Li Wang,Chenglin Zhang,Wei Zhao,Wei Li,Guodong Wang,Xuhui Zhou,Qiang Zhang
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2022-09-20
卷期号:5 (10): 4886-4895
被引量:4
标识
DOI:10.1021/acsabm.2c00609
摘要
Uncontrolled hemorrhage from wounds with deep and irregular cavities is short of efficient hemostats. Here we report a citric acid-cross-linked carboxymethyl cellulose nanofiber (CA-CMCNF) aerogel for the control of bleeding from penetrating wounds. The compressed CA-CMCNF aerogel could quickly swell into its original shape in water in seconds. The maximum mass and volume expansion ratios were over 6800 and 3000%, respectively. The water-swellable property allows the aerogel to self-expand and fill in the cavities of wounds. The in situ-generated expansion pressure resisted the systolic blood pressure, and the plentiful carboxyl groups triggered the active coagulation pathway, both contributing to the hemostatic capability of the aerogel. Additionally, the aerogel had good biocompatibility and excellent antibacterial capability. The animal experiments revealed that the aerogels significantly reduced both the hemostasis time and the amount of bleeding in a liver penetrating model. Therefore, this study provides a safe and robust hemostatic aerogel for controlling bleeding from penetrating wounds.
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