Generation 6 Polyamidoamine Dendrimer Provides an Ideal Nanoparticular Platform for Enzyme-assisted Synthesis of Glycopeptides Having Bulky and Complex Glycans

We demonstrate that generation 6 polyamidoamine dendrimer 7.2 nm in a diameter (MW = 58,048 Da) provides an ideal platform allowing for highly efficient enzymatic glycosylation of the peripheral bulky glycopeptidic substrates. Generation 6 polyamidoamine dendrimer 7.2 nm in diameter (MW = 58,048 Da) provides an ideal nanoparticular platform for the enzyme-assisted synthesis of highly complex glycopeptides having a bulky branched-type carbohydrates including sialyl Lewis antigens. The present strategy will facilitate the development of new class glyco-nanomedicines targeting disease-associated carbohydrate-recognizing receptors widely distributed on immune cell surfaces.