血管生成
萌芽血管生成
血管内皮生长因子A
薄壁组织
内皮干细胞
周细胞
生物
细胞生物学
病理
新生血管
医学
血管内皮生长因子
癌症研究
血管内皮生长因子受体
体外
遗传学
作者
Laëtitia Préau,Anna Lischke,Melanie Merkel,Neslihan Oegel,Maria Weissenbruch,Andria Michael,Hongryeol Park,Dietmar Gradl,Christian Kupatt,Ferdinand le Noble
标识
DOI:10.1038/s41467-024-47434-x
摘要
Formation of organo-typical vascular networks requires cross-talk between differentiating parenchymal cells and developing blood vessels. Here we identify a Vegfa driven venous sprouting process involving parenchymal to vein cross-talk regulating venous endothelial Vegfa signaling strength and subsequent formation of a specialized angiogenic cell, prefabricated with an intact lumen and pericyte coverage, termed L-Tip cell. L-Tip cell selection in the venous domain requires genetic interaction between vascular Aplnra and Kdrl in a subset of venous endothelial cells and exposure to parenchymal derived Vegfa and Apelin. Parenchymal Esm1 controls the spatial positioning of venous sprouting by fine-tuning local Vegfa availability. These findings may provide a conceptual framework for understanding how Vegfa generates organo-typical vascular networks based on the selection of competent endothelial cells, induced via spatio-temporal control of endothelial Kdrl signaling strength involving multiple parenchymal derived cues generated in a tissue dependent metabolic context.
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