材料科学
纳米颗粒
介孔材料
氧化物
纳米技术
层状双氢氧化物
介孔有机硅
药品
化学工程
介孔二氧化硅
冶金
有机化学
催化作用
医学
药理学
化学
工程类
氢氧化物
作者
Zongheng Li,Jing Yang,Bin Ren,Qingdeng Fan,Lin Huang,Shuai Guo,RuiLong Zhou,Sijin Chen,Jie Feng,Chenggong Yan,Xiaoyuan Chen,Zheyu Shen
标识
DOI:10.1002/adma.202313212
摘要
Cancer stem cells (CSCs) are one of the determinants of tumor heterogeneity and are characterized by self-renewal, high tumorigenicity, invasiveness, and resistance to various therapies. To overcome the resistance of traditional tumor therapies resulting from CSCs, a strategy of double drug sequential therapy (DDST) for CSC-enriched tumors is proposed in this study and is realized utilizing the developed double-layered hollow mesoporous cuprous oxide nanoparticles (DL-HMCONs). The high drug-loading contents of camptothecin (CPT) and all-trans retinoic acid (ATRA) demonstrate that the DL-HMCON can be used as a generic drug delivery system. ATRA and CPT can be sequentially loaded in and released from CPT3@ATRA3@DL-HMCON@HA. The DDST mechanisms of CPT3@ATRA3@DL-HMCON@HA for CSC-containing tumors are demonstrated as follows: 1) the first release of ATRA from the outer layer induces differentiation from CSCs with high drug resistance to non-CSCs with low drug resistance; 2) the second release of CPT from the inner layer causes apoptosis of non-CSCs; and 3) the third release of Cu
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