Profile of antibiotic resistance of the main infectious contaminants on the wound surface of wounded men in the Russian-Ukrainian war.

Aim: To study the spectrum of antibiotic resistance of causative agents of wound infection in wounded men at the stage of specialized medical care. Materials and Methods: Retrospective analysis of the results of culture of wound secretions on chromogenic media. The research involved 113 samples of biomaterial from 85 wounded. Sensitivity of antibiotics was studied by the Kirby-Bauer method. Results: Analysis of the microflora of the wound surface made it possible to determine the dominance of gram-negative bacteria, they were isolated in 80% of cases. The microbial spectrum of gram-negative bacteria is represented by Pseudomonas aeruginosa - 31 isolates, Acinetobacter baumannii - 29 isolates, Enterobacter aerogenes - 21 isolates, Proteus vulgaris - 13 isolates, Escherichia coli - 7 isolates, Enterobacter cloacae - 5 isolates, Klebsiella pneumoniae - 7 isolates and gram-positive bacteria Staphylococcus aureus - 5 isolates, Enterococcus fecalis - 32 isolates. Among all tested isolates of gram-negative non-fermenting bacteria and enterobacteria, the highest sensitivity was observed to colomycin and polymyxin B, from 60 to 80%. When analyzing of antibiotic sensitivity of Klebsiella pneumoniae and Acinetobacter baumannii, it was found that these pathogens retain 80-100% of their actual antibiotic sensitivity to polymyxins. Conclusions: Gram-negative strains isolated from wound infection are sensitive to antibiotics: 70% to polymyxins (colistin), 30% to aminoglycosides (amikacin), 24-16% to cephalosporins (cefoperazone-sulbactam/cefoperazone-avibactam).