纳米载体
光热治疗
材料科学
谷胱甘肽
纳米技术
生物物理学
过氧化氢
化学
纳米颗粒
有机化学
生物
酶
作者
Yanlin Zhu,Ruoxi Zhao,Lili Feng,Wenzhuo Wang,Ying Xie,He Ding,Bin Liu,Shuming Dong,Piaoping Yang,Jun Lin
标识
DOI:10.1002/smtd.202400125
摘要
Abstract Nanoformulations with endogenous/exogenous stimulus‐responsive characteristics show great potential in tumor cell elimination with minimal adverse effects and high precision. Herein, an intelligent nanotheranostic platform (denoted as TPZ@Cu‐SnS 2‐x /PLL) for tumor microenvironment (TME) and near‐infrared light (NIR) activated tumor‐specific therapy is constructed. Copper (Cu) doping and the resulting sulfur vacancies can not only improve the response range of visible light but also improve the separation efficiency of photogenerated carriers and increase the carrier density, resulting in the ideal photothermal and photodynamic performance. Density functional theory calculations revealed that the introduction of Cu and resulting sulfur vacancies can induce electron redistribution, achieving favorable photogenerated electrons. After entering cells through endocytosis, the TPZ@Cu‐SnS 2‐x /PLL nanocomposites show the pH responsivity property for the release of the TPZ selectively within the acidic TME, and the released Cu 2+ can first interact with local glutathione (GSH) to deplete GSH with the production of Cu + . Subsequently, the Cu + ‐mediated Fenton‐like reaction can decompose local hydrogen peroxide into hydroxyl radicals, which can also be promoted by hyperthermia derived from the photothermal effect for tumor cell apoptosis. The integration of photoacoustic/computed tomography imaging‐guided NIR phototherapy, TPZ‐induced chemotherapy, and GSH‐elimination/hyperthermia enhanced chemodynamic therapy results in synergistic therapeutic outcomes without obvious systemic toxicity in vivo.
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