适体
指数富集配体系统进化
癌症治疗
靶向治疗
癌症
计算生物学
纳米技术
药理学
医学
化学
生物
分子生物学
材料科学
生物化学
内科学
核糖核酸
基因
作者
Arash Mohammadinejad,Laura Găman,Ghazaleh Aleyaghoob,L. Gaceu,Seyed Ahmad Mohajeri,Marius Moga,Mihaela Badea
出处
期刊:Biosensors
[MDPI AG]
日期:2024-01-31
卷期号:14 (2): 78-78
被引量:6
摘要
Cancer is known as one of the most significant causes of death worldwide, and, in spite of novel therapeutic methods, continues to cause a considerable number of deaths. Targeted molecular diagnosis and therapy using aptamers with high affinity have become popular techniques for pathological angiogenesis and cancer therapy scientists. In this paper, several aptamer-based diagnostic and therapeutic techniques such as aptamer–nanomaterial conjugation, aptamer–drug conjugation (physically or covalently), and biosensors, which have been successfully designed for biomarkers, were critically reviewed. The results demonstrated that aptamers can potentially be incorporated with targeted delivery systems and biosensors for the detection of biomarkers expressed by cancer cells. Aptamer-based therapeutic and diagnostic methods, representing the main field of medical sciences, possess high potential for use in cancer therapy, pathological angiogenesis, and improvement of community health. The clinical use of aptamers is limited due to target impurities, inaccuracy in the systematic evolution of ligands via exponential enrichment (SELEX)stage process, and in vitro synthesis, making them unreliable and leading to lower selectivity for in vivo targets. Moreover, size, behavior, probable toxicity, low distribution, and the unpredictable behavior of nanomaterials in in vivo media make their usage in clinical assays critical. This review is helpful for the implementation of aptamer-based therapies which are effective and applicable for clinical use and the design of future studies.
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