材料科学
催化作用
互惠的
酶催化
热电性
纳米技术
组合化学
有机化学
光电子学
化学
哲学
语言学
电介质
铁电性
作者
Yan Wang,Rui Zhang,Pengyu Zang,Ruoxi Zhao,Linzhi Wu,Yanlin Zhu,Dan Yang,Shili Gai,Piaoping Yang
标识
DOI:10.1002/adma.202401111
摘要
Abstract Nanozyme activity is greatly weakened by the microenvironment and multidrug resistance of tumor cells. Hence, a bi‐catalytic nanoplatform, which promotes the anti‐tumor activity through “charging empowerment” and “mutual complementation” processes involved in enzymatic and pyroelectric catalysis, by loading ultra‐small nanoparticles (USNPs) of pyroelectric ZnSnO 3 onto MXene nanozyme (V 2 CT x nanosheets), is developed. Here, the V 2 CT x nanosheets exhibit enhanced peroxidase activity by reacting V 3+ with H 2 O 2 to generate toxic ·OH, accelerated by the near‐infrared (NIR) light mediated heat effect. The resulting V 4+ is then converted to V 3+ by oxidizing endogenous glutathione (GSH), realizing an enzyme‐catalyzed cycle. However, the cycle will lose its persistence once GSH is insufficient; nevertheless, the pyroelectric charges generated by ZnSnO 3 USNPs continuously support the V 4+ /V 3+ conversion and ensure nanoenzyme durability. Moreover, the hyperthermia arising from the V 2 CT x nanosheets by NIR irradiation results in an ideal local temperature gradient for the ZnSnO 3 USNPs, giving rise to an excellent pyroelectric catalytic effect by promoting band bending. Furthermore, polarized charges increase the tumor cell membrane permeability and facilitate nanodrug accumulation, thereby resolving the multidrug resistance issue. Thus, the combination of pyroelectric and enzyme catalysis together with the photothermal effect solves the dilemma of nanozymes and improves the antitumor efficiency.
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