Curcumin-gold nanoformulation: Synthesis, characterizations and biomedical application

Due to the different environmental and safety considerations, the green synthesized nanoparticles have been entered into various biomedical applications. As a result of the presence of numerous phytochemicals in the extracts, which often have different speeds and reaction paths and are unknown in many cases, metal nanoparticles synthesized from the extracts of various plants or other biological extracts usually have poor stability and low quality. Curcumin is a unique natural compound that not only presents many health benefits but also has been applied in the synthesis of many nanoparticle formulations of gold nanoparticles. In this review, every nanoformulation that contain gold nanoparticles and the natural phenolic compound of curcumin was investigated, and then the different aspect of synthesis and characterizations including biocompatibility, and antimicrobial and antioxidant efficacy of these formulation were reviewed. Due to the antioxidant properties of both gold nanoparticles and curcumin, most biological and medical applications of nanoparticles made or coated with curcumin are in the treatment or prevention of diseases such as diabetes, osteoarthritis, cancer, cardiovascular, and neurodegenerative diseases.