伤口愈合
纳米复合材料
生物相容性
聚乙烯醇
自愈水凝胶
材料科学
透明质酸
肿胀 的
抗菌活性
胶粘剂
壳聚糖
化学
高分子化学
纳米技术
医学
复合材料
细菌
外科
生物化学
图层(电子)
冶金
解剖
遗传学
生物
作者
Wen Jiang Zheng,Wenyue Yang,Wenlong Wei,Ziru Liu,Pier‐Luc Tremblay,Tian Zhang
标识
DOI:10.1002/adhm.202303138
摘要
Abstract Multifunctional hydrogel adhesives inhibiting infections and enabling the electrical stimulation (ES) of tissue reparation are highly desirable for the healing of surgical wounds and other skin injuries. Herein, a therapeutic nanocomposite hydrogel is designed by integrating β‐cyclodextrin‐embedded Ag nanoparticles ( CD AgNPs) in a polyvinyl alcohol (PVA) matrix enhanced with free β‐cyclodextrin (CD) and an atypical macromolecule made of β‐glucan grafted with hyaluronic acid (HAG). The main objective is to develop a biocompatible dressing combining the electroconductivity and antibacterial activity of CD AgNPs with the cohesiveness and porosity of PVA and the anti‐inflammatory, moisturizing, and cell proliferation‐promoting properties of HAG. The last component, CD, is added to strengthen the network structure of the hydrogel. PVA/CD/HAG/ CD AgNP exhibited excellent adhesion strength, biocompatibility, electroconductivity, and antimicrobial activity against a wide range of bacteria. In addition, the nanocomposite hydrogel has a swelling ratio and water retention capacity suitable to serve as a wound dressing. PVA/CD/HAG/ CD AgNP promoted the proliferation of fibroblast in vitro, accelerated the healing of skin wounds in an animal model, and is hemostatic. Upon ES, the PVA/CD/HAG/ CD AgNP nanocomposite hydrogel became more efficient both in vitro and in vivo further speeding up the skin healing process thus demonstrating its potential as a next‐generation electroconductive wound dressing.
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