光敏剂
免疫疗法
免疫系统
光动力疗法
癌症研究
佐剂
癌症免疫疗法
医学
化学
免疫学
有机化学
作者
Zijuan Meng,Tingting Wang,Yuxin Hu,Huiling Ouyang,Quan Wang,Meng Wu,Jian Zhou,Xiaoding Lou,Shixuan Wang,Jun Dai,Fan Xia
标识
DOI:10.1002/adhm.202302156
摘要
Abstract Surgery is a traditional tumor treatment, and immunotherapy can reduce the postoperative recurrence of tumors. However, the intrinsic limits of low responsive rate and non‐tumor specificity of immunotherapy agents are still insufficient to address therapeutic demands. Herein, the macrophages membrane camouflaged nanoparticles (NPs), named M@PFC, consisting of the aggregation‐induced emission photosensitizer (PF3‐PPh 3 ) and immune adjuvant (CpG), are reported. As the protein on the membrane interacts with the vascular cell adhesion molecule 1 (VCAM‐1) of cancer cells, M@PFC efficiently transports CpG to the tumor. Meanwhile, M@PFC can evade clearance by the immune system and prolong the circulation time in vivo; thus, enhancing their accumulation in tumors. PF3‐PPh 3 promotes high production of reactive oxygen species (ROS) and triggers immune cell death (ICD) in tumor cells under light exposure. Importantly, CpG enrichment in tumors can stimulate tumor cells to produce immune factors to assist in enhancing ICD effects. The synergistic effect combining the PDT properties of the aggregation‐induced emission (AIE)‐active photosensitizer and immunotherapy properties of CpG significantly delays tumor recurrence after surgery. In conclusion, this strategy achieves the synergistic activation of the immune system for anti‐tumor activity, providing a novel paradigm for the development of therapeutic nanodrugs to delay postoperative tumor recurrence.
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